Research Overview

My passion for research ignited when I was granted the opportunity to delve into a chemistry laboratory during my undergraduate journey. From that pivotal moment, I’ve been captivated by the intricate art of crafting and engineering small organic molecules, tailored for profound biological applications.

Throughout my trajectory in the realm of research, I’ve been engrossed in the synthesis of small molecules, meticulously designed to serve as ligands and inhibitors for pivotal proteins. My focus extends to their utilization as potential therapeutic agents, with a special emphasis on addressing rare diseases, like fibrolamellar carcinoma.

Beyond this, I’ve harnessed my skills to craft small-molecule carbohydrates, strategically engineered to inhibit ice recrystallization. This innovative endeavor aims to enhance the cryopreservation of crucial entities like red blood cells and hematopoietic stem cells, pushing the boundaries of preservation science.

I’ve been honored to share my research findings at various prestigious international and regional conferences, and publishing my work in peer-reviewed journals. 

Selected Publications

Antifreeze proteins solve cold problems

Ampaw, A. Nature Chemistry, 2022, 14(11), 1336–1336.

 

Designing the next generation of cryoprotectants – From proteins to small molecules.

Ampaw, A.; Charlton, T. A.; Briard, J. G.; Ben, R. N. Peptide Science 2018, 111(1), e24086

 

Observing enzyme ternary transition state analogue complexes by 19F NMR spectroscopy

Ampaw, A.; Carroll, M.; Bhattasali, D.; Cohen, A.; Jakeman. DL.; Chem. Sci. 2017, 8(12), 8427-8434.